Natural products remain one of the largest source of new drugs; for millions of years, we have relied on natural products, even in their crudest form, to treat a variety of ailments, from heart disease to skin warts. Chinese herbal medicines, particularly for the treatment of skin disorders have been in use for a long time. The inventions shown below are based on converting anecdotal use of Chinese medicine into a scientific portfolio, to make them better acceptable to regulatory agencies such as FDA that has recently started a new Division of Complimentary and Alternate Medicines to approve these drugs.
Topical ointment, containing extract of Huangqin, Huanglian, Huangbai, Opuntia, Dilong, and ß-sitosterol (from Soybean extract), in a vegetable oil-wax base, without any preservatives and more distinctly without opium that is common in Chinese products for topical application. The mechanism of action is stimulation of stem cells from ß-sitostero, while other components provide antiseptic and other healing action without scarring. Proven effective for treating second and third degree burns, stasis ulcers, trophic lesions, such as decubitus ulcers, diabetic ulcers, surgical wounds, severe cuts, diaper rash, cracked nipples and abrasions. PDF
Pharmaceutical compositions for the topical treatment of alopecia containing alcoholic extracts of Rhizoma zingiberis recens, Rhizoma pinelliae, Flos carthami, Radix rehmanniae, Radix angelicae sinesis, Radix paenoiae rubra, Cacumen biotae, Semen sesami nigrum, Radix polygoni multiflori, Fructus mori, Capsicum, Cantharidin, and Oleum ricini. Mechanism of action involves ß-cell stimulation, local irritation and dihdyrotestostrone level management. PDF
Compositions for treatment of existing and prevention of new skin scars containing alcoholic extracts of Cortex Phellodendri and Opuntia ficus indica. Effective in removing pregnancy stretch marks, surgical scars even chronic ones. PDF
Already marketed for the treatment of diaper rash in the US containing beeswax, olive oil, ß-sitosterol and the herb Coptis chinesis Franch for safe and quick treatment for infant and adult diaper rash. Free of any water-based component, the ointment also acts as humectant. PDF
US 6,365,198 | PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF GASTROINTESTINAL ULCERS AND HEMORRHOIDS.
Treatment of gastrointestinal ulcers and hemorrhoids for oral or rectal administration of extract of Huangqin, Huanglian, Huangbo, Opuntia and Pheretima dissolved in vegetable oil. PDF
Cauterization of wart with slaked lime followed by scratching the surface of wart with stem of betel leaf. PDF
Topical preparations for the treatment of topical itch containing Opuntia, Propolis, Stearic Acid, Beeswax, Vegetable Oil and ß-sitosterol. Itch includes scratch reaction itch, anal itch, or irritant itch due to plants (e.g., poison ivy), insect bite, sunburn, chemical itch, eczema, pruritis dermatitis, diabetic skin itch, aging skin itch, foot-itch, chickenpox, jock itch, hives, itch of healing burns and wounds, dry winter skin itch, and stress-related scalp itch, etc. PDF
US 10/250197 | COMPOSITIONS AND METHODS FOR REDUCING OR CONTROLLING BLOOD CHOLESTEROL, LIPOPROTEINS, TRIGLYCERIDES, AND SUGAR AND PREVENTING OR TREATING CARDIOVASCULAR DISEASES.
Oral product containing psyllium husk, ß-sitosterol, guggul tree extract, guar gum and chromium reduce or control blood cholesterol, triglycerides, low density lipoproteins, blood sugar or increasing or controlling high density lipoproteins and further reduce arterial plaque build-up, atherosclerosis associated with cardiovascular, cerebrovascular, peripheral vascular, or intestinal vascular disorders. PDF
Pharmaceutical compositions containing phystosterols and/or blood flow stimulants to promote hair growth through stimulation of follicular cells, bulb cells and stem cells in the scalp. PDF
US 09/957,773 | COMPOSITION AND METHOD FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA AND HYPERLIPIDEMIA IN MAMMALS.
Oral compositions containing Zizyphus jujube to treat atherosclerosis, post-angioplasty restenosis, coronary artery disease, angina, small artery disease and other diseases caused by or are the result of hypercholesterolemia. PDF
Compositions to reduce sebum production on the skin using a surfactant, a chylomicron disrupter, a skin penetration enhancer, and an anti-androgenic compound. PDF